MMS19 抗体
Quick Overview for MMS19 抗体 (ABIN7116477)
抗原
See all MMS19 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- MMS19 antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- MMS19 nucleotide excision repair homolog
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亚型
- IgG2a
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anti-MMS19 Nucleotide Excision Repair Homolog (MMS19) (AA 1-293) antibody
MMS19 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-MMS19 Nucleotide Excision Repair Homolog (MMS19) (AA 851-950) antibodyMMS19 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-MMS19 Nucleotide Excision Repair Homolog (MMS19) (Internal Region) antibodyMMS19 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000-1:4000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))
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别名
- MMS19
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背景
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Synonyms: MMS19 nucleotide excision repair protein homolog (hMMS19)|MET18 homolog|MMS19-like protein|MMS19|MMS19L
Background: Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
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分子量
- 103 kDa
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基因ID
- 64210
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UniProt
- Q96T76
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途径
- Nuclear Hormone Receptor Binding
抗原
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