MAP4K2 抗体
Quick Overview for MAP4K2 抗体 (ABIN7116461)
抗原
See all MAP4K2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MAP4K2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- mitogen-activated protein kinase kinase kinase kinase 2
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 386-469) antibody
MAP4K2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (Internal Region) antibodyMAP4K2 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 551-820) antibodyMAP4K2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) antibodyMAP4K2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 1-820) antibodyMAP4K2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 36-85) antibodyMAP4K2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 斑马鱼, 犬, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 216-265) antibodyMAP4K2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 斑马鱼, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (N-Term) antibodyMAP4K2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (N-Term) antibodyMAP4K2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) (AA 321-349) antibodyMAP4K2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB32275 unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2))
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别名
- MAP4K2
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背景
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Synonyms: Mitogen-activated protein kinase kinase kinase kinase 2|B lymphocyte serine/threonine-protein kinase|Germinal center kinase (GC kinase)|MAPK/ERK kinase kinase kinase 2 (MEK kinase kinase 2, MEKKK 2)|Rab8-interacting protein|MAP4K2|GCK|RAB8IP
Background: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase(MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase(SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns(PAMPs) such as polyinosine-polycytidine(poly(IC)), lipopolysaccharides(LPS), lipid A, peptidoglycan(PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
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分子量
- 85-91 kDa, 58 kDa
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基因ID
- 5871
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UniProt
- Q12851
抗原
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