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MUL1 抗体

MUL1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7116330
发货至: 中国
  • 抗原 See all MUL1 抗体
    MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
    适用
    • 46
    • 23
    • 20
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 44
    • 2
    克隆类型
    • 45
    • 1
    多克隆
    标记
    • 19
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MUL1 antibody is un-conjugated
    应用范围
    • 44
    • 15
    • 15
    • 14
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    mitochondrial E3 ubiquitin ligase 1
    亚型
    IgG
    Top Product
    Discover our top product MUL1 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000, IHC: 1:20-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
    别名
    MUL1 (MUL1 产品)
    别名
    C1orf166 antibody, GIDE antibody, MAPL antibody, MULAN antibody, RNF218 antibody, RP11-401M16.2 antibody, mul1 antibody, zgc:92166 antibody, 0610009K11Rik antibody, AV000801 antibody, Gide antibody, RGD1309944 antibody, im:7146383 antibody, zgc:165594 antibody, mitochondrial E3 ubiquitin protein ligase 1 antibody, mitochondrial E3 ubiquitin protein ligase 1 L homeolog antibody, mitochondrial E3 ubiquitin protein ligase 1a antibody, mitochondrial ubiquitin ligase activator of NFKB 1 antibody, mitochondrial E3 ubiquitin protein ligase 1b antibody, MUL1 antibody, mul1.L antibody, mul1a antibody, Mul1 antibody, mul1b antibody
    背景
    Synonyms:C1orf166, GIDE, MAPL, MULAN, RNF218 Background:Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
    分子量
    35 kDa
    基因ID
    79594
    UniProt
    Q969V5
    途径
    Positive Regulation of Endopeptidase Activity