MUL1 抗体
Quick Overview for MUL1 抗体 (ABIN7116330)
抗原
See all MUL1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MUL1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- mitochondrial E3 ubiquitin ligase 1
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亚型
- IgG
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anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 45-95) antibody
MUL1 适用: 人, 小鼠, 大鼠 WB, IF (p), FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (Middle Region) antibodyMUL1 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 1-352) antibodyMUL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 176-210) antibodyMUL1 适用: 人 WB 宿主: 兔 Polyclonal RB49942 unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 1-352) antibodyMUL1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 216-265) antibodyMUL1 适用: 人, 犬, 豚鼠, 马, 兔, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1) (AA 143-192) antibodyMUL1 适用: 人, 小鼠, 犬, 豚鼠, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
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别名
- MUL1
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背景
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Synonyms: Mitochondrial ubiquitin ligase activator of NFKB 1|E3 SUMO-protein ligase MUL1|E3 ubiquitin-protein ligase MUL1|Growth inhibition and death E3 ligase|Mitochondrial-anchored protein ligase|Protein Hades|Putative NF-kappa-B-activating protein 266|RING finger protein 218|RING-type E3 ubiquitin transferase NFKB 1|MUL1|C1orf166|GIDE|MAPL|MULAN|RNF218
Background: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.
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分子量
- 35 kDa
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基因ID
- 79594
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UniProt
- Q969V5
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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