MCM8 抗体
Quick Overview for MCM8 抗体 (ABIN7116318)
抗原
See all MCM8 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MCM8 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- minichromosome maintenance complex component 8
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- MCM8 (Minichromosome Maintenance Deficient 8 (MCM8))
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别名
- MCM8
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背景
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Synonyms: DNA helicase MCM8|Minichromosome maintenance 8|MCM8|C20orf154
Background: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex(pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex(ORC). Binds chromatin throughout the cell cycle.
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分子量
- 95 kDa
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基因ID
- 84515
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UniProt
- Q9UJA3
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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