MICAL2 抗体
Quick Overview for MICAL2 抗体 (ABIN7116286)
抗原
See all MICAL2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MICAL2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- microtubule associated monoxygenase, calponin and LIM domain containing 2
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亚型
- IgG
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anti-Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2) (AA 1-495) antibody
MICAL2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2) (AA 55-83), (N-Term) antibodyMICAL2 适用: 人 WB 宿主: 兔 Polyclonal RB18640 unconjugated
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应用备注
- IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))
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别名
- MICAL2
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背景
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Synonyms: [F-actin]-monooxygenase MICAL2|MICAL C-terminal-like protein (Mical-cL)|Molecule interacting with CasL protein 2 (MICAL-2)|MICAL2|KIAA0750|MICAL2PV1|MICAL2PV2|MICALCL
Background: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
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分子量
- 95, 112 kDa
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基因ID
- 9645
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UniProt
- O94851
抗原
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