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MEIS2 抗体

This anti-MEIS2 antibody is a 兔 多克隆 antibody detecting MEIS2 in WB, ELISA 和 IHC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7116144
发货至: 中国

Quick Overview for MEIS2 抗体 (ABIN7116144)

抗原

See all MEIS2 抗体
MEIS2 (Meis Homeobox 2 (MEIS2))

适用

  • 40
  • 16
  • 8
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
人, 小鼠, 大鼠

宿主

  • 35
  • 5
  • 1

克隆类型

  • 28
  • 13
多克隆

标记

  • 24
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This MEIS2 antibody is un-conjugated

应用范围

  • 30
  • 18
  • 11
  • 11
  • 3
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Meis homeobox 2

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000, IHC: 1:20-1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    MEIS2 (Meis Homeobox 2 (MEIS2))

    别名

    MEIS2

    背景

    Synonyms:MRG1 Background:Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex(PTF1) bound to the enhancer A element, MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3', in cooperation with a PBX protein(such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor(DRD1) promoter and activate DRD1 transcription, isoform 5 cannot activate DRD1 transcription.

    分子量

    56kd

    基因ID

    4212

    UniProt

    O14770
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