LRRC8D 抗体
Quick Overview for LRRC8D 抗体 (ABIN7115814)
抗原
See all LRRC8D 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- LRRC8D antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- leucine rich repeat containing 8 family, member D
-
亚型
- IgG
-
-
anti-Leucine Rich Repeat Containing 8 Family, Member D (LRRC8D) (AA 1-143) antibody
LRRC8D 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3H1-1C2 unconjugated
-
-
应用备注
- WB: 1:500-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- LRRC8D (Leucine Rich Repeat Containing 8 Family, Member D (LRRC8D))
-
别名
- LRRC8D
-
背景
-
Synonyms: Volume-regulated anion channel subunit LRRC8D|Leucine-rich repeat-containing protein 5|Leucine-rich repeat-containing protein 8D (HsLRRC8D)|LRRC8D|LRRC5
Background: Non-essential component of the volume-regulated anion channel(VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member(LRRC8B, LRRC8C, LRRC8D or LRRC8E), channel characteristics depend on the precise subunit composition(PubMed:24790029, PubMed:26824658). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin(PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell(PubMed:24782309).
-
分子量
- 98-120 kDa
-
基因ID
- 55144
-
UniProt
- Q7L1W4
抗原
-
