KLHL12 抗体
Quick Overview for KLHL12 抗体 (ABIN7115590)
抗原
See all KLHL12 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- KLHL12 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- kelch-like 12(Drosophila)
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亚型
- IgG
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anti-Kelch-Like 12 (Drosophila) (KLHL12) (AA 1-220) antibody
KLHL12 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) antibodyKLHL12 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) (N-Term) antibodyKLHL12 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) (AA 81-341) antibodyKLHL12 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) (N-Term) antibodyKLHL12 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch-Like 12 (Drosophila) (KLHL12) (AA 376-404), (C-Term) antibodyKLHL12 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB37184 unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- KLHL12 (Kelch-Like 12 (Drosophila) (KLHL12))
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别名
- KLHL12
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背景
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Synonyms: Kelch-like protein 12|CUL3-interacting protein 1|DKIR homolog (hDKIR)|KLHL12|C3IP1
Background: Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem(ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31(SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
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分子量
- 53-56 kDa, 63-67 kDa
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基因ID
- 59349
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UniProt
- Q53G59
抗原
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