KPNA5 抗体
Quick Overview for KPNA5 抗体 (ABIN7115574)
抗原
See all KPNA5 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- KPNA5 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- karyopherin alpha 5(importin alpha 6)
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亚型
- IgG
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anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (AA 1-539) antibody
KPNA5 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 1D2 unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (AA 1-539) antibodyKPNA5 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (AA 1-240) antibodyKPNA5 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (N-Term) antibodyKPNA5 适用: 人, 小鼠 WB, ELISA, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (AA 434-483) antibodyKPNA5 适用: 人, Cow, 犬, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Karyopherin alpha 5 (Importin alpha 6) (KPNA5) (N-Term) antibodyKPNA5 适用: 人, 小鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))
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别名
- KPNA5
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背景
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Synonyms: Importin subunit alpha-6|Karyopherin subunit alpha-5|KPNA5
Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
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分子量
- 60 kDa
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基因ID
- 3841
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UniProt
- O15131
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途径
- Protein targeting to Nucleus
抗原
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