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KPNA5 抗体

This anti-KPNA5 antibody is a 兔 多克隆 antibody detecting KPNA5 in WB 和 ELISA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN7115574
发货至: 中国

Quick Overview for KPNA5 抗体 (ABIN7115574)

抗原

See all KPNA5 抗体
KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

适用

  • 22
  • 6
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 21
  • 1

克隆类型

  • 21
  • 1
多克隆

标记

  • 17
  • 1
  • 1
  • 1
  • 1
  • 1
This KPNA5 antibody is un-conjugated

应用范围

  • 21
  • 14
  • 6
  • 4
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), ELISA
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    karyopherin alpha 5(importin alpha 6)

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:2000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

    别名

    KPNA5

    背景

    Synonyms: Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex(NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and-beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

    分子量

    60 kDa

    基因ID

    3841

    UniProt

    O15131

    途径

    Protein targeting to Nucleus
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