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IFIT3 抗体

IFIT3 适用: 人, 小鼠 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7115384
发货至: 中国
  • 抗原 See all IFIT3 抗体
    IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))
    适用
    • 42
    • 4
    • 3
    • 2
    • 1
    • 1
    人, 小鼠
    宿主
    • 39
    • 4
    克隆类型
    • 41
    • 2
    多克隆
    标记
    • 25
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IFIT3 antibody is un-conjugated
    应用范围
    • 36
    • 13
    • 13
    • 13
    • 9
    • 8
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunoprecipitation (IP)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    interferon-induced protein with tetratricopeptide repeats 3
    亚型
    IgG
    Top Product
    Discover our top product IFIT3 Primary Antibody
  • 应用备注
    WB: 1:500-1:1000, IP: 1:500-1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))
    别名
    IFIT3 (IFIT3 产品)
    背景
    Synonyms:CIG-49, IFI60, IFIT4, ISG60 Background:IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
    分子量
    60 kDa
    基因ID
    3437
    UniProt
    O14879
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