ITGB1BP1 抗体
Quick Overview for ITGB1BP1 抗体 (ABIN7115324)
抗原
See all ITGB1BP1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- integrin beta 1 binding protein 1
-
亚型
- IgG
-
-
anti-Integrin beta 1 Binding Protein 1 (ITGB1BP1) (AA 1-200) antibody
ITGB1BP1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Integrin beta 1 Binding Protein 1 (ITGB1BP1) (AA 1-200) antibodyITGB1BP1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 1 Binding Protein 1 (ITGB1BP1) antibodyITGB1BP1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin beta 1 Binding Protein 1 (ITGB1BP1) (AA 101-200) antibodyITGB1BP1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Integrin beta 1 Binding Protein 1 (ITGB1BP1) (AA 101-200) antibodyITGB1BP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3G4 unconjugated
anti-Integrin beta 1 Binding Protein 1 (ITGB1BP1) (AA 101-200) antibodyITGB1BP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E7 unconjugated
-
-
应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
-
有效期
- 12 months
-
-
- ITGB1BP1 (Integrin beta 1 Binding Protein 1 (ITGB1BP1))
-
别名
- ITGB1BP1
-
背景
- Synonyms:ICAP1 Background:Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1(heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion(FA) site dynamics by controlling its assembly rate during cell adhesion, inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor(GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion, reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation, modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development, acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.
-
分子量
- 22 kDa
-
基因ID
- 9270
-
UniProt
- O14713
-
途径
- Tube Formation
抗原
-
