INTS3 抗体
Quick Overview for INTS3 抗体 (ABIN7115305)
抗原
See all INTS3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- INTS3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- integrator complex subunit 3
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亚型
- IgG
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anti-Integrator Complex Subunit 3 (INTS3) (AA 518-551) antibody
INTS3 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB56744 unconjugated
anti-Integrator Complex Subunit 3 (INTS3) (AA 960-998) antibodyINTS3 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Integrator Complex Subunit 3 (INTS3) (AA 901-1043) antibodyINTS3 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrator Complex Subunit 3 (INTS3) (AA 1000-1034) antibodyINTS3 适用: 人 WB 宿主: 兔 Polyclonal RB56745 unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- INTS3 (Integrator Complex Subunit 3 (INTS3))
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别名
- INTS3
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背景
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Synonyms: Integrator complex subunit 3 (Int3)|SOSS complex subunit A|Sensor of single-strand DNA complex subunit A (SOSS-A, Sensor of ssDNA subunit A)|INTS3|C1orf193|C1orf60
Background: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs(snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain(CTD) of RNA polymerase II largest subunit(POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks(DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
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分子量
- 118 kDa
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基因ID
- 65123
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UniProt
- Q68E01
抗原
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