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INPP5D 抗体

INPP5D 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7115261
发货至: 中国
  • 抗原 See all INPP5D 抗体
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    适用
    • 75
    • 56
    • 37
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 75
    • 1
    克隆类型
    • 63
    • 13
    多克隆
    标记
    • 28
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
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    • 2
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    This INPP5D antibody is un-conjugated
    应用范围
    • 53
    • 19
    • 15
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    inositol polyphosphate-5-phosphatase, 145kDa
    亚型
    IgG
    Top Product
    Discover our top product INPP5D Primary Antibody
  • 应用备注
    WB: 1:500 - 1:2000, IF: 1:20 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    别名
    INPP5D (INPP5D 产品)
    背景
    Synonyms:SHIP, SHIP1 Background:Phosphatidylinositol(PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate(PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K(phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor(FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
    分子量
    145 kDa
    基因ID
    3635
    UniProt
    Q92835
    途径
    TCR Signaling, BCR Signaling, Warburg Effect
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