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INPP5D 抗体

This anti-INPP5D antibody is a 兔 多克隆 antibody detecting INPP5D in WB, ELISA 和 IF. Suitable for 人 和 小鼠.
产品编号 ABIN7115261
发货至: 中国

Quick Overview for INPP5D 抗体 (ABIN7115261)

抗原

See all INPP5D 抗体
INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

适用

  • 84
  • 62
  • 42
  • 20
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
人, 小鼠

宿主

  • 83
  • 2

克隆类型

  • 70
  • 15
多克隆

标记

  • 35
  • 5
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This INPP5D antibody is un-conjugated

应用范围

  • 62
  • 22
  • 17
  • 7
  • 6
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (IF)
  • 纯化方法

    Immunogen affinity purified

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    inositol polyphosphate-5-phosphatase, 145kDa

    亚型

    IgG
  • 应用备注

    WB: 1:500 - 1:2000, IF: 1:20 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

    别名

    INPP5D

    背景

    Synonyms:SHIP, SHIP1 Background:Phosphatidylinositol(PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate(PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K(phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor(FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.

    分子量

    145 kDa

    基因ID

    3635

    UniProt

    Q92835

    途径

    TCR Signaling, BCR Signaling, Warburg Effect
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