IPO13 抗体
Quick Overview for IPO13 抗体 (ABIN7115209)
抗原
See all IPO13 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- IPO13 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- importin 13
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亚型
- IgG
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anti-Importin 13 (IPO13) (C-Term) antibody
IPO13 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Importin 13 (IPO13) (AA 501-700) antibodyIPO13 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Importin 13 (IPO13) (AA 764-963) antibodyIPO13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Importin 13 (IPO13) antibodyIPO13 适用: 人 ELISA, WB, IHC 宿主: 兔 unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- IPO13 (Importin 13 (IPO13))
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别名
- IPO13
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背景
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Synonyms: Importin-13 (Imp13)|Karyopherin-13 (Kap13)|Ran-binding protein 13 (RanBP13)|IPO13|KIAA0724|RANBP13
Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
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分子量
- 97 kDa
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基因ID
- 9670
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UniProt
- O94829
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Protein targeting to Nucleus
抗原
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