HTRA1 抗体
Quick Overview for HTRA1 抗体 (ABIN7115116)
抗原
See all HTRA1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- HTRA1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- HtrA serine peptidase 1
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亚型
- IgG
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anti-HtrA Serine Peptidase 1 (HTRA1) (AA 116-147), (N-Term) antibody
HTRA1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB02326 unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (AA 23-248) antibodyHTRA1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) antibodyHTRA1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (AA 204-364) antibodyHTRA1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (AA 304-442) antibodyHTRA1 适用: E. coli WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (AA 381-412), (C-Term) antibodyHTRA1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB02327 unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (AA 22-160) antibodyHTRA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (AA 122-171) antibodyHTRA1 适用: 人, Cow, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (N-Term) antibodyHTRA1 适用: 人, 小鼠, 大鼠, Cow, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 1 (HTRA1) (AA 389-419), (C-Term) antibodyHTRA1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- HTRA1 (HtrA Serine Peptidase 1 (HTRA1))
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别名
- HTRA1
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背景
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Synonyms: Serine protease HTRA1|High-temperature requirement A serine peptidase 1|L56|Serine protease 11|HTRA1|HTRA|PRSS11
Background: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors(IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
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分子量
- 35 kDa, 50kD, 42 kDa
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基因ID
- 5654
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UniProt
- Q92743
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途径
- Growth Factor Binding
抗原
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