HCFC1 抗体
Quick Overview for HCFC1 抗体 (ABIN7115110)
抗原
See all HCFC1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- HCFC1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- host cell factor C1(VP16-accessory protein)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- HCFC1 (Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1))
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别名
- HCFC1
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背景
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Synonyms: Host cell factor 1 (HCF, HCF-1)|C1 factor|CFF|VCAF|VP16 accessory protein|HCF N-terminal chain 1|HCF N-terminal chain 2|HCF N-terminal chain 3|HCF N-terminal chain 4|HCF N-terminal chain 5|HCF N-terminal chain 6|HCF C-terminal chain 1|HCF C-terminal chain 2|HCF C-terminal chain 3|HCF C-terminal chain 4|HCF C-terminal chain 5|HCF C-terminal chain 6|HCFC1|HCF1|HFC1
Background: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2, represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase(H3K4me) and Sin3 histone deacetylase(HDAC) complexes(involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus(HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
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分子量
- 230 kDa, 300 kDa
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基因ID
- 3054
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UniProt
- P51610
抗原
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