HPSE 抗体
Quick Overview for HPSE 抗体 (ABIN7114948)
抗原
See all HPSE 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- HPSE antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- heparanase
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亚型
- IgG
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anti-Heparanase (HPSE) (AA 34-115) antibody
HPSE 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 353-464) antibodyHPSE 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 40-188) antibodyHPSE 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 280-412) antibodyHPSE 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 400-543) antibodyHPSE 适用: 人 WB, ICC, IF 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Heparanase (HPSE) (AA 36-275) antibodyHPSE 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 68-117) antibodyHPSE 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) antibodyHPSE 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 263-523) antibodyHPSE 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Heparanase (HPSE) (AA 72-170) antibodyHPSE 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D7 unconjugated
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应用备注
- WB: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- HPSE (Heparanase (HPSE))
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别名
- HPSE
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背景
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Synonyms: Heparanase|Endo-glucoronidase|Heparanase-1 (Hpa1)|Heparanase 8 kDa subunit|Heparanase 50 kDa subunit|HPSE|HEP|HPA|HPA1|HPR1|HPSE1|HSE1
Background: Endoglycosidase that cleaves heparan sulfate proteoglycans(HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix(ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix(ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.
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分子量
- 60 kDa
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基因ID
- 10855
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UniProt
- Q9Y251
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途径
- Glycosaminoglycan Metabolic Process
抗原
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