GPSM1 抗体
Quick Overview for GPSM1 抗体 (ABIN7114427)
抗原
See all GPSM1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- GPSM1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- G-protein signaling modulator 1(AGS3-like, C. elegans)
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亚型
- IgG
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应用备注
- WB: 1:200-1:2000, IF: 1:10-1:100, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- GPSM1 (G-Protein Signaling Modulator 1 (GPSM1))
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别名
- GPSM1
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背景
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Synonyms: G-protein-signaling modulator 1|Activator of G-protein signaling 3|GPSM1|AGS3
Background: GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory(GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate(GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein(p-CREB).
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分子量
- 72 kDa
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基因ID
- 26086
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UniProt
- Q86YR5
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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