GPR161 抗体
Quick Overview for GPR161 抗体 (ABIN7114407)
抗原
See all GPR161 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- GPR161 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- G protein-coupled receptor 161
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
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别名
- GPR161
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背景
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Synonyms: G-protein coupled receptor 161|G-protein coupled receptor RE2|GPR161
Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown(By similarity).
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分子量
- 70 kDa
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基因ID
- 23432
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UniProt
- Q8N6U8
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途径
- cAMP Metabolic Process
抗原
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