FOXP3 抗体
Quick Overview for FOXP3 抗体 (ABIN7114310)
抗原
See all FOXP3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- FOXP3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- forkhead box P3
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亚型
- IgG
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anti-Forkhead Box P3 (FOXP3) (AA 190-412) antibody
FOXP3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (C-Term) antibodyVerified FOXP3 适用: 小鼠 FACS, IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 297-431) antibodyFOXP3 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 4F12A2 unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibodyFOXP3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (C-Term) antibodyVerified FOXP3 适用: 人 WB, FACS, IHC, ELISA, IF, ICC 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (N-Term) antibodyFOXP3 适用: 人, 小鼠, 大鼠, Cow, Pig, 兔, 马, 犬, 绵羊, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 191-412) antibodyFOXP3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D1 unconjugated
anti-Forkhead Box P3 (FOXP3) (AA 1-431) antibodyFOXP3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box P3 (FOXP3) antibody (APC)FOXP3 适用: 人, 小鼠 ICFC 宿主: 小鼠 Monoclonal 3G3 APC
anti-Forkhead Box P3 (FOXP3) (AA 101-431) antibodyFOXP3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- FOXP3 (Forkhead Box P3 (FOXP3))
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别名
- FOXP3
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背景
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Synonyms: Forkhead box protein P3|Scurfin|Forkhead box protein P3, C-terminally processed|Forkhead box protein P3 41 kDa form|FOXP3|IPEX
Background: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells(Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2(IL2) and interferon-gamma(IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2(PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7(PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1(PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells(Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development(PubMed:18368049). Inhibits the transcriptional activator activity of RORA(PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4(By similarity).
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分子量
- 50 kDa
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基因ID
- 50943
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UniProt
- Q9BZS1
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途径
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
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