FAM20C 抗体 (AA 102-330)
Quick Overview for FAM20C 抗体 (AA 102-330) (ABIN7114089)
抗原
See all FAM20C 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 102-330
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原理
- FAM20C antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 102-330 aa
Immunogen: family with sequence similarity 20, member C
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- FAM20C (Family with Sequence Similarity 20, Member C (FAM20C))
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别名
- FAM20C
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背景
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Synonyms: Extracellular serine/threonine protein kinase FAM20C|Dentin matrix protein 4 (DMP-4)|Golgi casein kinase|Golgi-enriched fraction casein kinase (GEF-CK)|FAM20C|DMP4
Background: Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth(PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome(PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity(PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1(PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion(PubMed:26091039).
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分子量
- 50 kDa
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基因ID
- 56975
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UniProt
- Q8IXL6
抗原
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