BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) 抗体
This anti- antibody is a 兔 多克隆 antibody detecting in WB, IHC, ELISA 和 IF. Suitable for 人, 小鼠 和 大鼠.
Quick Overview for BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) 抗体 (ABIN7114081)
抗原
BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)
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原理
- ABRAXAS1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- family with sequence similarity 175, member A
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亚型
- IgG
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应用备注
- WB: 1:500-1:2400, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)
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别名
- ABRAXAS1
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背景
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Synonyms: BRCA1-A complex subunit Abraxas 1|Coiled-coil domain-containing protein 98|Protein FAM175A|ABRAXAS1|ABRA1|CCDC98|FAM175A
Background: Involved in DNA damage response and double-strand break(DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
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分子量
- 46 kDa
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基因ID
- 84142
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UniProt
- Q6UWZ7
抗原
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