SUPT16H 抗体
Quick Overview for SUPT16H 抗体 (ABIN7114058)
抗原
See all SUPT16H 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- SUPT16H antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- suppressor of Ty 16 homolog
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- SUPT16H (FACT complex subunit SPT16 (SUPT16H))
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别名
- SUPT16H
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背景
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Synonyms: FACT complex subunit SPT16|Chromatin-specific transcription elongation factor 140 kDa subunit|FACT 140 kDa subunit|FACTp140|Facilitates chromatin transcription complex subunit SPT16 (hSPT16)|SUPT16H|FACT140|FACTP140
Background: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2(casein kinase II).
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分子量
- 140 kDa
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基因ID
- 6830
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UniProt
- Q9Y5B9
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途径
- Chromatin Binding
抗原
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