FBXO18 抗体
This anti-FBXO18 antibody (ABIN7114057) is a Rabbit Polyclonal antibody detecting FBXO18 in WB, ELISA. Suitable for Human, Mouse, Rat.
Quick Overview for FBXO18 抗体 (ABIN7114057)
抗原
See all FBXO18 抗体
FBXO18
(F-Box Protein, Helicase, 18 (FBXO18))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This FBXO18 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA
-
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- F-box protein, helicase, 18
-
亚型
- IgG
-
-
anti-F-Box Protein, Helicase, 18 (FBXO18) antibody
FBXO18 适用: 人 DB, ICC 宿主: 小鼠 Monoclonal 2353C1a unconjugated
-
-
应用备注
- WB: 1:500-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
-
有效期
- 12 months
-
-
- FBXO18 (F-Box Protein, Helicase, 18 (FBXO18))
-
别名
- FBXO18
-
背景
- Synonyms:FBH1, FBX18 Background:3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks(PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination(PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress(PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal(PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location(PubMed:25585578).
-
分子量
- 118-123 kDa
-
基因ID
- 84893
-
UniProt
- Q8NFZ0
抗原
-
You are here:
