FBXO18 抗体
This anti-FBXO18 antibody is a 兔 多克隆 antibody detecting FBXO18 in WB 和 ELISA. Suitable for 人, 小鼠 和 大鼠.
Quick Overview for FBXO18 抗体 (ABIN7114057)
抗原
See all FBXO18 抗体
FBXO18
(F-Box Protein, Helicase, 18 (FBXO18))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This FBXO18 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- F-box protein, helicase, 18
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亚型
- IgG
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anti-F-Box Protein, Helicase, 18 (FBXO18) antibody
FBXO18 适用: 人 DB, ICC 宿主: 小鼠 Monoclonal 2353C1a unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- FBXO18 (F-Box Protein, Helicase, 18 (FBXO18))
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别名
- FBXO18
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背景
- Synonyms:FBH1, FBX18 Background:3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks(PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination(PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress(PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal(PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location(PubMed:25585578).
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分子量
- 118-123 kDa
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基因ID
- 84893
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UniProt
- Q8NFZ0
抗原
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