FBXO9 抗体
Quick Overview for FBXO9 抗体 (ABIN7114056)
抗原
See all FBXO9 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- F-box protein 9
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亚型
- IgG
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anti-F-Box Protein 9 (FBXO9) (AA 13-111) antibody
FBXO9 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 338-447) antibodyFBXO9 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G12 unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 1-437) antibodyFBXO9 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (Middle Region) antibodyFBXO9 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 马, Pig, 兔, 豚鼠, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) antibodyFBXO9 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 179-228) antibodyFBXO9 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡, 马, Pig, 兔, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 346-373), (C-Term) antibodyFBXO9 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- FBXO9 (F-Box Protein 9 (FBXO9))
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别名
- FBXO9
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背景
- Synonyms:FBX9, VCIA1 Background:Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
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分子量
- 52 kDa
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基因ID
- 26268
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UniProt
- Q9UK97
抗原
-
