FBXO6 抗体
Quick Overview for FBXO6 抗体 (ABIN7114053)
抗原
See all FBXO6 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- FBXO6 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- F-box protein 6
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亚型
- IgG
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anti-F-Box Protein 6 (FBXO6) (AA 104-293) antibody
FBXO6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 6 (FBXO6) (AA 1-293) antibodyFBXO6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box Protein 6 (FBXO6) (AA 1-293) antibodyFBXO6 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-F-Box Protein 6 (FBXO6) (AA 1-293) antibodyFBXO6 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 7D1 unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- FBXO6 (F-Box Protein 6 (FBXO6))
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别名
- FBXO6
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背景
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Synonyms: F-box only protein 6|F-box protein that recognizes sugar chains 2|F-box/G-domain protein 2|FBXO6|FBG2|FBS2|FBX6
Background: Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
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分子量
- 35 kDa
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基因ID
- 26270
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UniProt
- Q9NRD1
抗原
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