FBXW11 抗体
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北京 101111
Quick Overview for FBXW11 抗体 (ABIN7114038)
抗原
See all FBXW11 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- FBXW11 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- F-box and WD repeat domain containing 11
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亚型
- IgG
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anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (AA 1-140) antibody
FBXW11 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (AA 1-140) antibodyFBXW11 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (AA 1-529) antibodyFBXW11 适用: 人 ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (AA 168-196) antibodyFBXW11 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18056 unconjugated
anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (AA 175-204), (Middle Region) antibodyFBXW11 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (N-Term) antibodyFBXW11 适用: 人, 小鼠, 犬, 豚鼠, 兔, 小鸡, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (AA 38-87) antibodyFBXW11 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 11 (FBXW11) (N-Term) antibodyFBXW11 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- FBXW11 (F-Box and WD Repeat Domain Containing 11 (FBXW11))
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别名
- FBXW11
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背景
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Synonyms: F-box/WD repeat-containing protein 11|F-box and WD repeats protein beta-TrCP2|F-box/WD repeat-containing protein 1B|Homologous to Slimb protein (HOS)|FBXW11|BTRCP2|FBW1B|FBXW1B|KIAA0696
Background: Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68, this is required for centriole separation during mitosis(PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1(HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.
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分子量
- 61 kDa
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基因ID
- 23291
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UniProt
- Q9UKB1
抗原
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