EXOSC1 抗体
Quick Overview for EXOSC1 抗体 (ABIN7114007)
抗原
See all EXOSC1 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- exosome component 1
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亚型
- IgG
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anti-Exosome Component 1 (EXOSC1) (AA 1-195) antibody
EXOSC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E9 unconjugated
anti-Exosome Component 1 (EXOSC1) (AA 1-195) antibodyEXOSC1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Exosome Component 1 (EXOSC1) (AA 9-195) antibodyEXOSC1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 1 (EXOSC1) (AA 587-762) antibodyEXOSC1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Exosome Component 1 (EXOSC1) (AA 1-195) antibodyEXOSC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- EXOSC1 (Exosome Component 1 (EXOSC1))
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别名
- EXOSC1
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背景
- Synonyms:CSL4 Background:Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits(Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
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分子量
- 21 kDa
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基因ID
- 51013
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UniProt
- Q9Y3B2
抗原
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