EIF4A3 抗体
Quick Overview for EIF4A3 抗体 (ABIN7113966)
抗原
See all EIF4A3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- EIF4A3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- eukaryotic translation initiation factor 4A, isoform 3
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亚型
- IgG
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anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 6-166) antibody
EIF4A3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 351-411) antibodyEIF4A3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 1-210) antibodyEIF4A3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 312-411) antibodyEIF4A3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 1-50) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig IHC, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 125-175) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 斑马鱼, 小鸡, 非洲爪蟾 WB, IHC, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 136-185) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, Cow, 豚鼠, 马, 小鸡, Pig, 非洲爪蟾, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 51-100) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, Cow, 豚鼠, 马, 小鸡, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, C. elegans WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (N-Term) antibodyEIF4A3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))
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别名
- EIF4A3
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背景
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Synonyms: Eukaryotic initiation factor 4A-III (eIF-4A-III, eIF4A-III)|ATP-dependent RNA helicase DDX48|ATP-dependent RNA helicase eIF4A-3|DEAD box protein 48|Eukaryotic initiation factor 4A-like NUK-34|Eukaryotic translation initiation factor 4A isoform 3|Nuclear matrix protein 265 (NMP 265, hNMP 265)|Eukaryotic initiation factor 4A-III, N-terminally processed|EIF4A3|DDX48|KIAA0111
Background: ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex(EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay(NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X(and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly. Involved in craniofacial development.
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分子量
- 47 kDa
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基因ID
- 9775
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UniProt
- P38919
抗原
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