EIF2AK1 抗体 (AA 1-194)
Quick Overview for EIF2AK1 抗体 (AA 1-194) (ABIN7113933)
抗原
See all EIF2AK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-194
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原理
- EIF2AK1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 1-194aa
Immunogen: eukaryotic translation initiation factor 2-alpha kinase 1
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亚型
- IgG
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anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 1-86) antibody
EIF2AK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (N-Term) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 108-157) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠, 猴, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (N-Term) antibodyEIF2AK1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) antibodyEIF2AK1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 1-630) antibodyEIF2AK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (C-Term) antibodyEIF2AK1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 371-630) antibodyEIF2AK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (C-Term) antibodyEIF2AK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
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别名
- EIF2AK1
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背景
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Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 1|Heme-controlled repressor (HCR)|Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase|Heme-regulated inhibitor (hHRI)|Hemin-sensitive initiation factor 2-alpha kinase|EIF2AK1|HRI|KIAA1369
Background: Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells(RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions(By similarity).
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分子量
- 60-71 kDa
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基因ID
- 27102
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UniProt
- Q9BQI3
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途径
- Hepatitis C
抗原
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