EGLN3 抗体
Quick Overview for EGLN3 抗体 (ABIN7113751)
抗原
See all EGLN3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- EGLN3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- egl nine homolog 3
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:500-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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别名
- EGLN3
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背景
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Synonyms: Prolyl hydroxylase EGLN3|Egl nine homolog 3|HPH-1|Hypoxia-inducible factor prolyl hydroxylase 3 (HIF-PH3, HIF-prolyl hydroxylase 3, HPH-3)|Prolyl hydroxylase domain-containing protein 3 (PHD3)|EGLN3
Background: EGLN3, also named as HPH-1, HIF-PH3, HPH-3 and PHD3, is a cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor(HIF) alpha proteins. It hydroxylates a specific proline found in each of the oxygen-dependent degradation(ODD) domains(N-terminal, NODD, and C-terminal, CODD) of HIF1A. It is a regulator of cardiomyocyte and neuronal apoptosis. EGLN3 can be a prognostic marker for gastric cancer.
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分子量
- 28 kDa
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UniProt
- Q9H6Z9
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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