DNA Helicase B 抗体
HELB
适用: 人
WB, ELISA, IF
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all DNA Helicase B (HELB) 抗体
- DNA Helicase B (HELB)
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DNA Helicase B antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- helicase(DNA) B
- 亚型
- IgG
- Top Product
- Discover our top product HELB Primary Antibody
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anti-DNA Helicase B (HELB) (AA 77-126) antibody
HELB 适用: 人, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Helicase B (HELB) (N-Term) antibodyHELB 适用: 人, Pig, Cow, 豚鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000, IF: 1:20-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- DNA Helicase B (HELB)
- 别名
- HELB (HELB 产品)
- 别名
- RGD1560103 antibody, hDHB antibody, AI447783 antibody, D10Ertd664e antibody, DNA helicase B antibody, helicase (DNA) B antibody, Helb antibody, HELB antibody
- 背景
- Synonyms: Background:5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection(PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA(ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB(PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation(PubMed:26774285). Acts independently of TP53BP1(PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates(PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress(PubMed:22194613).
- 分子量
- 120-140 kDa
- 基因ID
- 391723
- UniProt
- Q8NG08
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