DNA Helicase B 抗体
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北京 101111
Quick Overview for DNA Helicase B 抗体 (ABIN7113549)
抗原
See all DNA Helicase B (HELB) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- HELB antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- helicase(DNA) B
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亚型
- IgG
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anti-DNA Helicase B (HELB) (AA 77-126) antibody
HELB 适用: 人, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Helicase B (HELB) (N-Term) antibodyHELB 适用: 人, Pig, Cow, 豚鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- DNA Helicase B (HELB)
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别名
- HELB
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背景
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Synonyms: DNA helicase B (hDHB)|HELB
Background: 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection(PubMed:25617833, PubMed:26774285). Recruitment to single-stranded DNA(ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB(PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation(PubMed:26774285). Acts independently of TP53BP1(PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates(PubMed:12181327). During S phase, may facilitate cellular recovery from replication stress(PubMed:22194613).
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分子量
- 120-140 kDa
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基因ID
- 391723
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UniProt
- Q8NG08
抗原
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