DCLRE1B 抗体
Quick Overview for DCLRE1B 抗体 (ABIN7113546)
抗原
See all DCLRE1B 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- DCLRE1B antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)
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亚型
- IgG
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anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 208-236) antibody
DCLRE1B 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB26835 unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (C-Term) antibodyDCLRE1B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 345-493) antibodyDCLRE1B 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 323-532) antibodyDCLRE1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
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别名
- DCLRE1B
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背景
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Synonyms: 5' exonuclease Apollo|Beta-lactamase DCLRE1B|DNA cross-link repair 1B protein|SNM1 homolog B (SNMIB, hSNM1B)|DCLRE1B|SNM1B
Background: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining(NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop(T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase(TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links(ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
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分子量
- 60 kDa
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基因ID
- 64858
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UniProt
- Q9H816
抗原
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