DHX36 抗体
Quick Overview for DHX36 抗体 (ABIN7113365)
抗原
See all DHX36 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- DHX36 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- DEAH(Asp-Glu-Ala-His) box polypeptide 36
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亚型
- IgG
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anti-DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 (DHX36) (AA 1-260) antibody
DHX36 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 (DHX36) (AA 68-181) antibodyDHX36 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- DHX36 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 (DHX36))
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别名
- DHX36
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背景
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Synonyms: ATP-dependent DNA/RNA helicase DHX36|DEAD/H box polypeptide 36|DEAH-box protein 36|G4-resolvase-1 (G4R1)|MLE-like protein 1|RNA helicase associated with AU-rich element protein|DHX36|DDX36|KIAA1488|MLEL1|RHAU
Background: Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component(TERC) 5'-end(nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation, the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.
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分子量
- 120 kDa
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基因ID
- 170506
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UniProt
- Q9H2U1
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途径
- Toll-Like Receptors Cascades
抗原
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