CLASP2 抗体
Quick Overview for CLASP2 抗体 (ABIN7113293)
抗原
See all CLASP2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CLASP2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- cytoplasmic linker associated protein 2
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CLASP2 (Cytoplasmic Linker Associated Protein 2 (CLASP2))
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别名
- CLASP2
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背景
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Synonyms: CLIP-associating protein 2|Cytoplasmic linker-associated protein 2|Protein Orbit homolog 2 (hOrbit2)|CLASP2|KIAA0627
Background: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules(PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network(TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2(PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle(PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
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分子量
- 140-160 kDa
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基因ID
- 23122
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UniProt
- O75122
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途径
- Microtubule Dynamics, Maintenance of Protein Location
抗原
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