CNDP2 抗体
Quick Overview for CNDP2 抗体 (ABIN7112896)
抗原
See all CNDP2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CNDP2 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- CNDP dipeptidase 2(metallopeptidase M20 family)
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CNDP2 (CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2))
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别名
- CNDP2
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背景
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Synonyms: Cytosolic non-specific dipeptidase|CNDP dipeptidase 2|Glutamate carboxypeptidase-like protein 1|Peptidase A|Threonyl dipeptidase|CNDP2|CN2|CPGL|HEL-S-13|PEPA
Background: Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly(PubMed:19346245). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase(MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation(PubMed:24395568). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma(HCC) cells(PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis(PubMed:25964343).
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分子量
- 54 kDa
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基因ID
- 55748
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UniProt
- Q96KP4
抗原
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