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CPSF3 抗体

CPSF3 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7112880
发货至: 中国
  • 抗原 See all CPSF3 抗体
    CPSF3 (Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3))
    适用
    • 38
    • 10
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 32
    • 6
    克隆类型
    • 34
    • 4
    多克隆
    标记
    • 28
    • 2
    • 2
    • 2
    • 2
    • 2
    This CPSF3 antibody is un-conjugated
    应用范围
    • 36
    • 16
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    cleavage and polyadenylation specific factor 3, 73kDa
    亚型
    IgG
    Top Product
    Discover our top product CPSF3 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    CPSF3 (Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3))
    别名
    CPSF3 (CPSF3 产品)
    别名
    CPSF3 antibody, si:dkey-81b15.1 antibody, wu:fc32f10 antibody, zgc:101655 antibody, CPSF-73 antibody, CPSF73 antibody, cleavage and polyadenylation specific factor 3 antibody, cleavage and polyadenylation specificity factor subunit 3 antibody, cleavage and polyadenylation specific factor 3 L homeolog antibody, cleavage and polyadenylation specific factor 3, 73kDa antibody, cleavage and polyadenylation specificity factor 3 antibody, CPSF3 antibody, cpsf3 antibody, CpipJ_CPIJ011955 antibody, CMU_024380 antibody, PITG_07110 antibody, cpsf3.L antibody, Cpsf3 antibody
    背景
    Synonyms:CPSF73 Background:Component of the cleavage and polyadenylation specificity factor(CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3'-endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product(DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop(SL) and 5' phosphate on the downstream cleavage product(DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product(DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner.
    分子量
    77kd
    基因ID
    51692
    UniProt
    Q9UKF6
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