CHI3L1 抗体 (AA 22-383)
Quick Overview for CHI3L1 抗体 (AA 22-383) (ABIN7112692)
抗原
See all CHI3L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 22-383
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原理
- CHI3L1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 22-383aa
Immunogen: chitinase 3-like 1(cartilage glycoprotein-39)
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亚型
- IgG
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应用备注
- IHC: 1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))
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别名
- CHI3L1
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背景
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Synonyms: Chitinase-3-like protein 1|39 kDa synovial protein|Cartilage glycoprotein 39 (CGP-39, GP-39, hCGP-39)|YKL-40|CHI3L1
Background: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2(Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
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分子量
- 43 kDa
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基因ID
- 1116
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UniProt
- P36222
抗原
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