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CX3CL1 抗体 (AA 90-245)

This 小鼠 单克隆 anti-CX3CL1 antibody (Clone 5D1) specifically detects CX3CL1 in WB, IHC 和 ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN7112685
发货至: 中国
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中国
北京 101111
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Room 801-803
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Quick Overview for CX3CL1 抗体 (AA 90-245) (ABIN7112685)

抗原

See all CX3CL1 抗体
CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CX3CL1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), ELISA

克隆位点

5D1
  • 抗原表位

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    AA 90-245

    原理

    CX3CL1 antibody

    纯化方法

    Protein A+G purification

    纯度

    ≥95 % as determined by SDS-PAGE

    免疫原

    Immunogen sequence: 90-245aa

    Immunogen: chemokine(C-X3-C motif) ligand 1

    亚型

    IgG1
  • 应用备注

    WB: 1:500-1:2000, IHC: 1:50-1:500

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    -20 °C

    储存方法

    -20°C for 12 months

    有效期

    12 months
  • 抗原

    CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))

    别名

    CX3CL1

    背景

    Synonyms: Fractalkine|C-X3-C motif chemokine 1|CX3C membrane-anchored chemokine|Neurotactin|Small-inducible cytokine D1|Processed fractalkine|CX3CL1|FKN|NTT|SCYD1

    Background: Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350).

    分子量

    90 kDa

    基因ID

    6376

    UniProt

    P78423

    途径

    Synaptic Membrane
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