CX3CL1 抗体 (AA 90-245)
Quick Overview for CX3CL1 抗体 (AA 90-245) (ABIN7112685)
抗原
See all CX3CL1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 90-245
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原理
- CX3CL1 antibody
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纯化方法
- Protein A+G purification
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
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Immunogen sequence: 90-245aa
Immunogen: chemokine(C-X3-C motif) ligand 1
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亚型
- IgG1
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应用备注
- WB: 1:500-1:2000, IHC: 1:50-1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))
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别名
- CX3CL1
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背景
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Synonyms: Fractalkine|C-X3-C motif chemokine 1|CX3C membrane-anchored chemokine|Neurotactin|Small-inducible cytokine D1|Processed fractalkine|CX3CL1|FKN|NTT|SCYD1
Background: Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1(PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site(site 1) in integrins. In the absence of CX3CR1, binds to a second site(site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1(PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium(PubMed:9024663, PubMed:9177350).
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分子量
- 90 kDa
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基因ID
- 6376
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UniProt
- P78423
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途径
- Synaptic Membrane
抗原
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