CHMP6 抗体
Quick Overview for CHMP6 抗体 (ABIN7112649)
抗原
See all CHMP6 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- CHMP6 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- chromatin modifying protein 6
-
亚型
- IgG
-
-
anti-Charged Multivesicular Body Protein 6 (CHMP6) (AA 2-201) antibody
CHMP6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 6 (CHMP6) antibodyCHMP6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 6 (CHMP6) antibodyCHMP6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:500-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))
-
别名
- CHMP6
-
背景
-
Synonyms: Charged multivesicular body protein 6|Chromatin-modifying protein 6|Vacuolar protein sorting-associated protein 20 (Vps20, hVps20)|CHMP6|VPS20
Background: Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
-
分子量
- 28-30 kDa
-
基因ID
- 79643
-
UniProt
- Q96FZ7
抗原
-
