CHMP1A 抗体
Quick Overview for CHMP1A 抗体 (ABIN7112643)
抗原
See all CHMP1A 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CHMP1A antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- chromatin modifying protein 1A
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亚型
- IgG
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anti-Charged Multivesicular Body Protein 1A (CHMP1A) (AA 1-196) antibody
CHMP1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 1A (CHMP1A) antibodyCHMP1A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 1A (CHMP1A) (AA 1-196) antibodyCHMP1A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 1A (CHMP1A) (AA 51-150) antibodyCHMP1A 适用: 人, 小鼠 IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 1A (CHMP1A) antibodyCHMP1A 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 1A (CHMP1A) (AA 1-196) antibodyCHMP1A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))
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别名
- CHMP1A
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背景
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Synonyms: Charged multivesicular body protein 1a|Chromatin-modifying protein 1a (CHMP1a)|Vacuolar protein sorting-associated protein 46-1 (Vps46-1, hVps46-1)|CHMP1A|CHMP1|KIAA0047|PCOLN3|PRSM1
Background: Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group(PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
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分子量
- 33 kDa, 25 kDa
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基因ID
- 5119
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UniProt
- Q9HD42
抗原
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