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RAD1 抗体

RAD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7112556
发货至: 中国
  • 抗原 See all RAD1 抗体
    RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))
    适用
    • 33
    • 12
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 29
    • 4
    • 1
    克隆类型
    • 32
    • 2
    多克隆
    标记
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAD1 antibody is un-conjugated
    应用范围
    • 25
    • 17
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    RAD1 homolog(S. pombe)
    亚型
    IgG
    Top Product
    Discover our top product RAD1 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    RAD1 (Cell Cycle Checkpoint Protein RAD1 (RAD1))
    别名
    RAD1 (RAD1 产品)
    别名
    HRAD1 antibody, REC1 antibody, zgc:56502 antibody, zgc:77779 antibody, RAD1 antibody, xrad1 antibody, DKFZp459H1127 antibody, RAD1 checkpoint DNA exonuclease antibody, RAD1 homolog (S. pombe) antibody, RAD1 antibody, Rad1 antibody, rad1 antibody
    背景
    Synonyms:REC1 Background:Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C(RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair(LP-BER). The 9-1-1 complex stimulates DNA polymerase beta(POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I(LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks(DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity.
    分子量
    32 kDa
    基因ID
    5810
    UniProt
    O60671
    途径
    M Phase
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