CNOT7 抗体
Quick Overview for CNOT7 抗体 (ABIN7112436)
抗原
See all CNOT7 抗体适用
宿主
克隆类型
标记
应用范围
-
-
原理
- CNOT7 antibody
-
纯化方法
- Immunogen affinity purified
-
纯度
- ≥95 % as determined by SDS-PAGE
-
免疫原
- CCR4-NOT transcription complex, subunit 7
-
亚型
- IgG
-
-
-
-
应用备注
- WB: 1:500-1:2000, IP: 1:200-1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freeze / thaw cycles.
-
储存条件
- -20 °C
-
储存方法
- -20°C for 12 months
-
有效期
- 12 months
-
-
- CNOT7 (CCR4-NOT Transcription Complex, Subunit 7 (CNOT7))
-
别名
- CNOT7
-
背景
-
Synonyms: CCR4-NOT transcription complex subunit 7|BTG1-binding factor 1|CCR4-associated factor 1 (CAF-1)|Caf1a|CNOT7|CAF1
Background: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
-
分子量
- 33-35 kDa
-
基因ID
- 29883
-
UniProt
- Q9UIV1
-
途径
- Ribonucleoprotein Complex Subunit Organization
抗原
-