CNOT3 抗体
Quick Overview for CNOT3 抗体 (ABIN7112435)
抗原
See all CNOT3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CNOT3 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- CCR4-NOT transcription complex, subunit 3
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亚型
- IgG
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IF: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CNOT3 (CCR4-NOT Transcription Complex, Subunit 3 (CNOT3))
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别名
- CNOT3
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背景
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Synonyms: CCR4-NOT transcription complex subunit 3|CCR4-associated factor 3|Leukocyte receptor cluster member 2|CNOT3|KIAA0691|LENG2|NOT3
Background: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation, may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation, the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem(ES) cell identity.
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分子量
- 120 kDa
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基因ID
- 4849
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UniProt
- O75175
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途径
- Stem Cell Maintenance
抗原
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