CNOT1 抗体
Quick Overview for CNOT1 抗体 (ABIN7112432)
抗原
See all CNOT1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CNOT1 antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- CCR4-NOT transcription complex, subunit 1
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亚型
- IgG
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anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 2137-2376) antibody
CNOT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CCR4-NOT Transcription Complex, Subunit 1 (CNOT1) (AA 604-867) antibodyCNOT1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
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别名
- CNOT1
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背景
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Synonyms: CCR4-NOT transcription complex subunit 1|CCR4-associated factor 1|Negative regulator of transcription subunit 1 homolog (NOT1H, hNOT1)|CNOT1|CDC39|KIAA1007|NOT1
Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity.
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分子量
- 240-250 kDa, 174 kDa
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基因ID
- 23019
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UniProt
- A5YKK6
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途径
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
抗原
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