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CARD9 抗体

CARD9 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7112379
发货至: 中国
  • 抗原 See all CARD9 抗体
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    适用
    • 35
    • 3
    • 2
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 33
    • 3
    克隆类型
    • 35
    • 1
    多克隆
    标记
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CARD9 antibody is un-conjugated
    应用范围
    • 35
    • 13
    • 13
    • 9
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Immunogen affinity purified
    纯度
    ≥95 % as determined by SDS-PAGE
    免疫原
    caspase recruitment domain family, member 9
    亚型
    IgG
    Top Product
    Discover our top product CARD9 Primary Antibody
  • 应用备注
    WB: 1:500-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    有效期
    12 months
  • 抗原
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    别名
    CARD9 (CARD9 产品)
    别名
    Gm782 antibody, card9 antibody, CANDF2 antibody, hCARD9 antibody, caspase recruitment domain family, member 9 antibody, caspase recruitment domain family member 9 antibody, Card9 antibody, CARD9 antibody, card9 antibody
    背景
    Synonyms: Background:Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors(TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases(MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B(By similarity). Controls CLEC7A(dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A(dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper(TH-17) cells.
    分子量
    50-59kd
    基因ID
    64170
    UniProt
    Q9H257
    途径
    Activation of Innate immune Response
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