CREB3 抗体
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- 抗原 See all CREB3 抗体
- CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CREB3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- cAMP responsive element binding protein 3
- 亚型
- IgG
- Top Product
- Discover our top product CREB3 Primary Antibody
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anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 273-371) antibody
CREB3 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 3H5 unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-230) antibodyCREB3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-230) antibodyCREB3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) antibodyCREB3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 1-371) antibodyCREB3 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 311-344), (C-Term) antibodyCREB3 适用: 人 WB 宿主: 兔 Polyclonal RB50244 unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (C-Term) antibodyCREB3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 247-296) antibodyCREB3 适用: 人, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) antibodyCREB3 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-CAMP Responsive Element Binding Protein 3 (CREB3) (AA 76-87) antibodyVerified CREB3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))
- 别名
- CREB3 (CREB3 产品)
- 别名
- LUMAN antibody, LZIP antibody, AU044960 antibody, AW538053 antibody, C80076 antibody, LZIP-1 antibody, LZIP-2 antibody, Luman antibody, creb3 antibody, luman antibody, lzip antibody, cAMP responsive element binding protein 3 antibody, cAMP responsive element binding protein 3 S homeolog antibody, CREB3 antibody, Creb3 antibody, creb3.S antibody
- 背景
- Synonyms:LZIP Background:Endoplasmic reticulum(ER)-bound transcription factor that plays a role in the unfolded protein response(UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1(HIV-1) virus protein expression and in the herpes simplex virus-1(HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response(UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus(HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases(HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells. Processed cyclic AMP-responsive element-binding protein 3: acts as a transcription factor that activates unfolded protein response(UPR) target genes during endoplasmic reticulum(ER) stress response. Promotes cell survival against ER stress-induced apoptotic cell death during UPR. Activates transcription from CRE and C/EBP-containing reporter genes. Induces transcriptional activation of chemokine receptors. Activates transcription of genes required for reactivation of the latent HSV-1 virus. Down-regulates Tat-dependent transcription of the HIV-1 LTR by interacting with HIV-1 Tat. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16 and by the HCV core protein. Binds DNA to the cAMP response element(CRE)(consensus: 5'-GTGACGT[AG][AG]-3') and C/EBP sequences present in many viral and cellular promoters. Binds to the unfolded protein respons element(UPRE) consensus sequences sites. Binds DNA to the 5'-CCAC[GA]-3'half of ERSE II(5'-ATTGG-N-CCACG-3'). Associates with chromatin to the HERPUD1 promoter.
- 分子量
- 40-64 kDa
- 基因ID
- 10488
- UniProt
- O43889
- 途径
- Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response
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