BRCC3 抗体
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- 抗原 See all BRCC3 抗体
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
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适用
- 人, 小鼠, 大鼠, 猴
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BRCC3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- BRCA1/BRCA2-containing complex, subunit 3
- 亚型
- IgG
- Top Product
- Discover our top product BRCC3 Primary Antibody
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anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 14-316) antibody
BRCC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316), (N-Term) antibodyBRCC3 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal AT3B1 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 18-50) antibodyBRCC3 适用: 人 WB 宿主: 兔 Polyclonal RB53911 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 36-70) antibodyBRCC3 适用: 人 WB 宿主: 兔 Polyclonal RB54401 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) antibody (FITC)BRCC3 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) antibodyBRCC3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal AT3B1 unconjugated
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (C-Term) antibodyBRCC3 适用: 人, 小鼠, 大鼠, 马, Pig, Cow, 豚鼠, 兔 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:2000, IHC: 1:20-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
- 别名
- BRCC3 (BRCC3 产品)
- 背景
- Synonyms:BRCC36, C6.1A, CXorf53 Background:Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains(PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks(DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks(DSBs)(PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates(PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex(CSN), via the interaction of the BRISC complex with the CSN complex(PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1(PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression(PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide(LPS) via its role in IFNAR1 deubiquitination(PubMed:24075985).
- 分子量
- 65-70kd
- 基因ID
- 79184
- UniProt
- P46736
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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